See all Attractions in Las Cruces Las Cruces for: Adventure, Food And Dining, Art And Culture, Nightlife, Spa, History, First Timers, Family, Romance, Shopping Las Cruces Railroad Museum About Las Cruces Railroad Museum. [10] 351 Mesilla St. (in the historic Santa Fe Depot), +1 575 647-4480. The museum interprets the impact of the railroad on the Mesilla Valley and Las Cruces. Open Th-Sa 10-4; free. Add to Wish List